# E36 [Catalog # P021]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/220822_40tskJXAIS3vgHrvQD?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/220837_SYKi5XMVhYvv8ke4Lw?q=80&s=1280x180&t=outside&f=webp)

**E36** is a selective RNA probe over DNA. **E36** was disclosed through in vitro DNA/RNA selectivity screening and live cell staining for nucleolus

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/220902_GXSvyWc3KHKj5NjD0r?q=80&s=1280x180&t=outside&f=webp)

Live Cell RNA Staining with Selected Dyes **E36**, E144, and F22 were tested at a 5 mM concentration. The picture of F22-stained 3T3 cells was obtained in a 1 mM dye concentration.
1000x magnification was utilized in the imaging. The scale bar represents 5 mm. Image brightness and contrast were slightly adjusted to improve picture quality. **E36**, E144 (green: FITC channel), and F22 (red: Cy3 channel) are shown.

■** Related probes**: E144, F22

■ **Known Property**
RNA probe
■ **Application**
Selective fluorescent imaging of nuclear structure in live cells
■ **Cell selectivity mechanism**
RNA

■ **Reference**

1. **RNA-selective, live cell imaging probes for studying nuclear structure and function.**, Li, Q., Kim, Y. K., Namm, J., Kulkarni, A., Rosania, G., Ahn, Y. H., Chang, Y. T.* Chem. Biol. 2006, 13, 615-623.

2. **A protocol for preparing, characterizing and using three RNA-specific, live cell imaging probes: E36**, E144 and F22 Li, Q.; Chang, Y. T.* Nat. Protoc. 2006, 1, 2922-2932.

3. **Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic wnt signaling**, Speese, S. D.; Ashley, J.; Jokhi, V.; Nunnari, J.; Barria, R.; Li, Y.; Ataman, B.; Koon, A.; Chang, Y. T.; Li, Q.; Moore, M. J.; Budnik, V. Cell 2012, 149, 832-846.

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDF file**

E36 data sheet v0.2.pdf

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