# BD-Tau [Catalog # P039]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250919/101037_v6JZaJtZ5hnqGUyjnl?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/224955_Wi5GoRRxYkg0Pqt0mP?q=80&s=1280x180&t=outside&f=webp)

**BD-tau**, a BODIPY-based fluorescence sensor detects pathological tau aggregates in live cells. As a fluorescence turn-on sensor, the quantum yield of BD-tau increased 3.8-fold upon binding to tau aggregates in vitro. β-sheet protein panel assay indicates that BD-tau also responds to other β-sheet protein aggregates such as amyloid plaques and insulin aggregates. However, compared with other conventional tau probes, BD-tau has superior selectivity to tau aggregates over amyloid plaques or insulin aggregates. As a cell-permeable imaging probe, BD-tau selectively labeled pathological tau aggregates in live hippocampal neurons.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/224937_hkQyTamK9VF5cXvi7Z?q=80&s=1280x180&t=outside&f=webp)

BD-tau labels tau aggregates in brain slices of a tau transgenic mouse model. The representative images of brain tissue stained with BD-tau and the anti-tau PHF antibody. Nuclei were counterstained with Hoechst. Scale bar = 100 mm.

■ **Related probes**: BD-Oligo, 2C40, 2E10

■ **Known Property**
Tau probe
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
unknown

■ **Reference**

1. **Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells**, Lim, S.; Haque, M. M.; Su, D.; Kim, D.; Lee, J. S.; Chang, Y. T.; Kim, Y. K. Chem. Commun. 2017, 53, 1607-1610.

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDF file**

BD-Tau data sheet v0.2.pdf

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