# BD-Oligo [Cataolg # P038]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250919/100959_Ygt2lxveSK3n3qUomn?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/225224_UHrRTmCw7wvMpzJWqJ?q=80&s=1280x180&t=outside&f=webp)

**BD-Oligo** demonstrates a dynamic oligomer-monitoring ability during Aβ peptide fibrillogenesis, as Aβ was induced to form oligomers and eventually fibrils over time. More importantly, BD-Oligo also shows BBB penetration with capabilities of staining Aβ oligomers in vivo.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/225259_Ex06nYKwE8riTAGjDk?q=80&s=1280x180&t=outside&f=webp)

Ex vivo binding of** BD-Oligo** in 18 month old AD mouse brains.  a, b and c show fluorescence in the APP/PS1 mouse brain injected with BD-Oligo using the channel for 6E10/4G8 labeling, BD-Oligo labeling and the merged image, respectively. BD-Oligo fluorescence was present in the brain 24 h after an I.P. injection of BD-Oligo (see b), which co-localized with the Aβ labeling (see c). Arrows indicate plaques with co-localization. d, e and f show fluorescence in the APP/PS1 mouse brain injected saline alone using the channel for 6E10/4G8 labeling, BD-Oligo labeling and the merged image, respectively. There are no plaques seen in the BD-Oligo channel in the control saline injected mice, indicating the specificity of the BD-Oligo oligomer labeling. Scale bar, 100µm.

■ **Related probes**: CDnir7

**■ Known Property**
Ab oligomer probe
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
unknown

■ **Known Property**
Ab oligomer probe
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
unknown

■ **Reference**

1. **A chemical fluorescent probe for the detection of Aß oligomers**, Teoh, C. L.; Su, D. D.; Sahu, S.; Yun, S. W.; Drummond, E.; Prelli, F.; Lim, S.; Cho, S.; Ham, S.; Wisniewski, T.; Chang, Y. T. J. Am. Chem. Soc., 2015, available online

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDF file**

BD-Oligo data sheet v0.2.pdf

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