# TiY [Catalog # P028]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/223138_AmfCWg2inikWEt0vhn?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/223152_yzoBXlEXmQWlfaDi56?q=80&s=1280x180&t=outside&f=webp)

The chloroacetyl motif of **TiY **facilitated the binding target protein from TS32 cells, elucidating vimentin as TiY’s target. Vimentin is an intermediate filament and EMT (Epithelial-mesenchymal transition) marker. **TiY** shows the inhibitor function against vimentin, and has higher affinity to tetramer comparing to monomer vimentin. At high dose, TiY suppresses the tumor sphere growth of TIC, without much effect to differentiated cancer cells or normal epithelial cells.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/223229_FJ4urc31mCrTNDLQ4a?q=80&s=1280x180&t=outside&f=webp)

Discovery of a fluorescent probe for lung TICs (A) S-cell-selective staining by TiY (B) Flow cytometry quadrant dot plot of 32A and TS32 cells after dual staining with TiY and CD166.

■ **Related probes**: TiNIR

■ **Known Property**
Tumor Initiating Cell (TIC) probe.
■ **Application**
Immunofluorescence and therapeutic treatment for TIC
■ **Cell selectivity mechanism**
 POLD (Vimentin)

■ **Reference**

1. **Identification of Tumor Initiating Cells by a Small Molecule Fluorescent Probe through Vimentin as the Biomarker**_, Lee, Y. A.; Kim, J. J.; Lee, J.; Lee, J. H. J.; Sahu, S.; Kwon, H. Y.; Park, S. J.; Jang, S. Y.; Lee, J. S.; Wang, Z.; Tam, W. L.; Lim, B.; Kang, N. Y.; Chang, Y. T._ Angew. Chem. Int. Ed. Engl. 2018, 57, 2851-2854.

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDF file**

TiY data sheet.pdf

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