# CDr17 [Patent pended]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250407/125935_2xVYmfujfg1wPspqXe?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250407/125953_tMOU4r0XHgB0N0hIqf?q=80&s=1280x180&t=outside&f=webp)

**CDr17** is selective for M1 macrophages over M2 and M0 macrophages. The selective staining mechanism of CDr17 is explained as Gating-Oriented Live-cell Distinction (GOLD) through overexpressed GLUT1 in M1 macrophages. Additionally,** CDr17** has been demonstrated to effectively track M1 macrophages in vivo in a rheumatoid arthritis animal model.

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250407/130041_ijX8Ai9gxQSTl0ydPg?q=80&s=1280x180&t=outside&f=webp)

Selectivity of **CDr17** to **M1** over M0 or M2 macrophages from RAW264.7 and relative fluorescent intensity (FI) of CDr17.

■ **Known Property**
M1 macrophage selective probe
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
GOLD (GLUT1)

■ **Reference**

1. **Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target. **Cho H, Kwon HY, Sharma A, Lee SH, Liu X, Miyamoto N, Kim JJ, Im SH, Kang NY, Chang YT.  Angew. Chem. Int. Ed. Engl. 2019, 58, 7972-7976.

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■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

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