# 2E10 [Catalog # P041]

**■ Chemical structure & Information**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/224331_Aspsak5XghPAxPyXCV?q=80&s=1280x180&t=outside&f=webp)

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/224402_UZtfEKU29dfhc4UfJq?q=80&s=1280x180&t=outside&f=webp)

A library of fluorescent styryl dyes (320 compounds) was prepared by solid-phase chemistry. The dyes were screened for their detection of amyloid aggregates, which are associated with diseases such as Alzheimer's, and two of the 320 compounds screened, 2C40 and **2E10**, showed promise as brain-imaging agents

**■ Cell Image**

![Image](https://upload.cafenono.com/image/slashpagePost/20250206/224309_vsfaKrOAqYEMuKOhA4?q=80&s=1280x180&t=outside&f=webp)

Labeling of amyloid deposits in a slice of mouse brain with 2E10 (green, indicated by arrows). c) Confocal microscopy image of amyloid deposits labeled with 2E10 (green) and ThS (blue); note that 2E10 preferentially labels the core of deposits Labeling of amyloid deposits.

■ **Related probes**: 2C40, BD-Oligo, BD-Tau

■ **Known Property**
Amyloid sensor
■ **Application**
Immunofluorescence
■ **Cell selectivity mechanism**
unknown

■ **Reference**

1. **Solid phase synthesis of styryl dye library and its application to amyloid sensors**, Li, Q.; Lee, J. S.; Ha, C.; Park, C. B.; Yang G.; Gan, W. B.; Chang, Y. T.* Angew. Chem., Int. Ed. Engl., 2004, 43, 6331-6335.

■ **ORDER**

**International**

**USD 350 + VAT (10%) + Fedex delivery charge**

**In Korea**

**KRW 450,000 + VAT (10%)**

**100 nmol** (dried form: equivalent to 1 mM / 100 µL)

[order@senprobe.com](mailto:order@senprobe.com)

■ **Storage**
① Delivery: Room Temperature
② Dried compound: 4°C or -20°C
③ Compound solution: 4°C or -20°C

■ **General Use Guide**

- More than 1/100 dilution of 10mM of DMSO stock solution is essential

-  For biomedical use to avoid DMSO concentration higher than 1%.

- Working concentrations for specific applications should be determined by the investigator.

- It is recommended to use up the buffer diluted solution within one day. The compound may be decomposed or
- precipitated out from buffer solution.

■ **Data sheet PDf file**

2E10 data sheet v0.2.pdf

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